| Autor: |
G N, Batrak, S E, Mogilevich, A I, Luĭk, V V, Prokopenko |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
Ukrains'kyi biokhimichnyi zhurnal (1999 ). 71(3) |
| Popis: |
The influence of physical and chemical properties of some sites of transmembrane receptor domains on the receptors ability to interact with nonspecific antagonists was investigated mathematically. The properties of sites located in 3rd and 7th transmembrane domains are most likely to explain pharmacological characteristics of the receptors. The possibility of receptor blocking by nonspecific antagonists not by competing with agonists but by influencing the receptor conformation is discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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