| Autor: |
L C, Chan, K K, Karhi, S I, Rayter, N, Heisterkamp, S, Eridani, R, Powles, S D, Lawler, J, Groffen, J G, Foulkes, M F, Greaves, L M, Wiedemann |
| Rok vydání: |
1987 |
| Předmět: |
|
| Zdroj: |
Nature. 325(6105) |
| ISSN: |
0028-0836 |
| Popis: |
The Philadelphia (Ph) chromosome breakpoints in chronic myelocytic leukaemia are clustered on chromosome 22 band q11 in a 5.8-kilobase (kb) region designated bcr. The c-abl protooncogene is translocated from chromosome 9 band q34 into bcr and the biochemical consequence of this molecular rearrangement is the production of an abnormal fusion protein bcr-abl p210 with enhanced protein-tyrosine kinase activity compared to the normal p145 c-abl protein. The Ph chromosome translocation is also seen in some acute lymphoblastic leukaemias with B-cell precursor phenotypes some of which have bcr rearrangement (bcr+) and some do not (bcr-). We present evidence that the Ph+, bcr- leukaemias are associated with a novel p190 abl kinase. We propose that acute lymphoblastic leukaemias that are bcr+, p210+ are probably lymphoid blast crises following a clinically silent chronic phase of chronic myelocytic leukaemia arising in multipotential stem cells whereas bcr-, p190+ cases are de novo acute lymphoblastic leukaemias arising in more restricted precursors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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