| Autor: |
J F, Cloix, M, Le Jossec, O, Baud, R, Pecquery, Y, Giudicelli, J P, Dausse |
| Jazyk: |
francouzština |
| Rok vydání: |
1992 |
| Předmět: |
|
| Zdroj: |
Comptes rendus des seances de la Societe de biologie et de ses filiales. 186(4) |
| ISSN: |
0037-9026 |
| Popis: |
Existing evidences indicate that a crossed regulation between alpha 2-adrenergic receptors and Na+/H+ exchanger(s) exists, that Na decreases the affinity of alpha 2-adrenergic receptors for agonists and antagonists, that intracellular Na+ and H+ ion concentrations regulate Na+/H+ exchanger activity, that intracellular pH controls the affinity of the alpha 2-adrenergic receptors for their agonists and antagonists. Alterations of alpha 2-adrenergic receptor densities and allosteric regulation by sodium have been demonstrated in sodium-dependent hypertension in rats. Increased Na+/H+ exchanger activity has been reported in genetic hypertension. Nevertheless, cosegregation experiments and human genetic polymorphism suggest that the exchanger could not be related to hypertension. We propose the following hypothesis: the increased Na+/H+ exchanger characteristic of hypertension could be secondary to the abnormalities of the alpha 2-adrenergic receptors found in hypertension, probably through the alteration of the sodium allosteric effect on these receptors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
