Genetic variability in tumor necrosis factor production: relevance to predisposition to autoimmune disease

Autor:	C O, Jacob
Rok vydání:	1992
Předmět:	Mice Gene Expression Regulation Tumor Necrosis Factor-alpha Genes MHC Class II Animals Genetic Variation Humans Lupus Erythematosus Systemic Autoimmune Diseases Diabetes Mellitus Experimental Malaria
Zdroj:	Regional immunology. 4(5)
ISSN:	0896-0623
Popis:	Rather than being involved merely in the effector arm of inflammatory processes that contribute to autoimmune organ destruction, a primary involvement of TNF may be in some of the more basic mechanisms that occur in autoimmune disease. In this review, data are presented on TNF-alpha that suggest the involvement of this cytokine in the genetic predisposition to autoimmune diseases such as lupus nephritis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8739a1173d411f2dcac7b52bff2d02fc https://pubmed.ncbi.nlm.nih.gov/1290749 Zobrazit plný text záznamu