| Autor: |
W O, Rogers, M A, Hall, R M, Brissie, C A, Robinson |
| Rok vydání: |
1997 |
| Předmět: |
|
| Zdroj: |
Journal of forensic sciences. 42(1) |
| ISSN: |
0022-1198 |
| Popis: |
Benzodiazepine abuse is common among clients at methadone maintenance clinics. Diazepam and lorazepam are readily detected by immunological screening methods and confirmed by GC/MS. Alprazolam has been relatively difficult to confirm. We recently reported a modification of an existing serum HPLC procedure which allows us to analyze whole blood. We report here three cases of fatal drug overdose caused by co-ingestion of methadone and alprazolam. In all three cases, alprazolam was detected by HPLC and could not be identified by alkaline extraction GC/MS. Postmortem blood concentrations of methadone were at the lower range or below the concentrations previously identified in methadone overdose fatalities, suggesting an increased risk from co-ingestion of methadone and alprazolam. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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