Antithrombotic activity of the superoxide dismutase-chondroitin sulfate complexes in a rat model of arterial injury

Autor:	A V, Maksimenko, E G, Tischenko, V L, Golubykh
Rok vydání:	2000
Předmět:	Male Dose-Response Relationship Drug Superoxide Dismutase Chondroitin Sulfates Thrombosis In Vitro Techniques Glycocalyx Rats Disease Models Animal Drug Combinations Carotid Arteries Drug Stability Fibrinolytic Agents Animals Ferrous Compounds
Zdroj:	Cardiovascular drugs and therapy. 13(6)
ISSN:	0920-3206
Popis:	Individual antithrombotic activities of superoxide dismutase (SOD) and sodium chondroitin sulfate (CHS) as well as the activities of covalent and noncovalent complexes of SOD with CHS were compared in a rat model of arterial thrombosis induced by ferrous chloride. Covalent conjugate of SOD with CHS exerted the most potent antithrombotic effect, which was associated with adsorption of the conjugate on the glycocalyx of the vascular wall cells and stability of the covalent bond between CHS and SOD subunits. Theoretical and practical directions in the investigation of SOD and CHS preparations are outlined.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::86db8dab3064cc7971e5d74821cfaa8c https://pubmed.ncbi.nlm.nih.gov/10686656 Zobrazit plný text záznamu Full text from SpringerLink