Effect of ketoconazole 2% shampoo on scalp sebum level in patients with seborrhoeic dermatitis

Autor:	H, Dobrev, L, Zissova
Rok vydání:	1997
Předmět:	Adult Male Ketoconazole Malassezia Scalp Treatment Outcome Adolescent Administration Topical Hair Preparations Humans Female Dermatitis Seborrheic
Zdroj:	Acta dermato-venereologica. 77(2)
ISSN:	0001-5555
Popis:	Twenty patients with scalp seborrhoeic dermatitis were treated twice weekly with ketoconazole 2% shampoo for 4 weeks. Clinical assessment, culture for P. ovale on Dixon broth and lipid measurement at two places were made before treatment and after 2 and 4 weeks. Significant improvement of the severity of seborrhoeic dermatitis (p0.001) and negative mycological tests by 19 (95%) of patients were observed. The scalp lipid content remained unaltered in 11 patients with an initial lipid value over 220 micrograms/cm2 but increased in those with lower initial values. This is probably due to the improvement of sebum delivery onto skin surface as a result of the elimination of the follicular occlusion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::86b46b508304808f438b84f5c9f9c5dc https://pubmed.ncbi.nlm.nih.gov/9111824 Zobrazit plný text záznamu