| Autor: |
Jialin, Chen, Aljona, Sitsel, Veronick, Benoy, M Rosario, Sepúlveda, Peter, Vangheluwe |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Cold Spring Harb Perspect Biol |
| ISSN: |
1943-0264 |
| Popis: |
Calcium ions (Ca(2+)) are prominent cell signaling effectors that regulate a wide variety of cellular processes. Among the different players in Ca(2+) homeostasis, primary active Ca(2+) transporters are responsible for keeping low basal Ca(2+) levels in the cytosol while establishing steep Ca(2+) gradients across intracellular membranes or the plasma membrane. This review summarizes our current knowledge on the three types of primary active Ca(2+)-ATPases: the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) pumps, the secretory pathway Ca(2+)- ATPase (SPCA) isoforms, and the plasma membrane Ca(2+)-ATPase (PMCA) Ca(2+)-transporters. We first discuss the Ca(2+) transport mechanism of SERCA1a, which serves as a reference to describe the Ca(2+) transport of other Ca(2+) pumps. We further highlight the common and unique features of each isoform and review their structure–function relationship, expression pattern, regulatory mechanisms, and specific physiological roles. Finally, we discuss the increasing genetic and in vivo evidence that links the dysfunction of specific Ca(2+)-ATPase isoforms to a broad range of human pathologies, and highlight emerging therapeutic strategies that target Ca(2+) pumps. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
