| Autor: |
Junke, Xia, Luping, Li, Fuhua, Duan, Jingjing, Meng, Shuping, Yan, Shenglei, Li, Huayan, Ren, Xiangdong, Kong |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. 37(8) |
| ISSN: |
1003-9406 |
| Popis: |
To explore the genetic basis for a patient with Leydig cell hypoplasia.Whole exome sequencing was used to detect genetic variants in the patient. Suspect variants were verified by PCR and Sanger sequencing of the family members.The patient was found to carry two novel variants, namely c.265AT (p.Ile189Leu) and c.422TC (p.Val141Ala), of the luteinizing hormone receptor gene (LHCGR), where were respectively inherited from her father and mother. Upon prenatal diagnosis, the fetus was found to be a heterozygous carrier of the c.265AT (p.Ile189Leu) variant.The compound heterozygous variants of c.265AT (p.Ile189Leu) and c.422TC (p.Val141Ala) of the LHCGR gene probably underlie the Leydig cell hypoplasia in the patient. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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