Resistance to 3-HTMC-Induced Apoptosis Through Activation of PI3K/Akt, MEK/ERK, and p38/COX-2/PGE
| Autor: | Josiane, Semaan, Aline, Pinon, Benjamin, Rioux, Lama, Hassan, Youness, Limami, Christelle, Pouget, Catherine, Fagnère, Vincent, Sol, Mona, Diab-Assaf, Alain, Simon, Bertrand, Liagre |
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| Rok vydání: | 2015 |
| Předmět: |
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Western MAP Kinase Kinase 1 Antineoplastic Agents Apoptosis p38 Mitogen-Activated Protein Kinases Dinoprostone Gene Expression Regulation Neoplastic Phosphatidylinositol 3-Kinases Chalcone Chalcones Cyclooxygenase 2 Drug Resistance Neoplasm Tumor Cells Cultured Humans Colorectal Neoplasms Extracellular Signal-Regulated MAP Kinases Proto-Oncogene Proteins c-akt |
| Zdroj: | Journal of cellular biochemistry. 117(12) |
| ISSN: | 1097-4644 |
| Popis: | Increasing incidence and mortality of colorectal cancer brings the necessity to uncover new possibilities in its prevention and treatment. Chalcones have been identified as interesting compounds having chemopreventive and antitumor properties. In this study, we investigated the effects of the synthetic chalcone derivative 3-hydroxy-3',4,4',5'-tetra-methoxy-chalcone (3-HTMC) on proliferation, cell cycle distribution, apoptosis, and its mechanism of action in human colorectal HT-29 (COX-2 sufficient) and HCT116 (COX-2 deficient) cancer cells. We showed that 3-HTMC decreased cell viability in a dose-dependent manner with a more potent antiproliferative effect on HCT116 than HT-29 cells. Flow cytometric analysis revealed G |
| Databáze: | OpenAIRE |
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