Targeting of the Cholecystokinin-2 Receptor with the Minigastrin Analog
| Autor: | Alexander W, Sauter, Rosalba, Mansi, Ulrich, Hassiepen, Lionel, Muller, Tania, Panigada, Stefan, Wiehr, Anna-Maria, Wild, Susanne, Geistlich, Martin, Béhé, Christof, Rottenburger, Damian, Wild, Melpomeni, Fani |
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| Rok vydání: | 2018 |
| Předmět: |
Radioisotopes
Single Photon Emission Computed Tomography Computed Tomography Biological Transport Lutetium Receptor Cholecystokinin B Heterocyclic Compounds 1-Ring Mice Drug Stability Cell Line Tumor Positron Emission Tomography Computed Tomography Gastrins Animals Humans Female Protease Inhibitors Tissue Distribution Amino Acid Sequence |
| Zdroj: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 60(3) |
| ISSN: | 1535-5667 |
| Popis: | Patients with metastatic medullary thyroid cancer (MTC) have limited systemic treatment options. The use of radiolabeled gastrin analogs targeting the cholecystokinin-2 receptor (CCK2R) is an attractive approach. However, their therapeutic efficacy is presumably decreased by their enzymatic degradation in vivo. We aimed to investigate whether the chemically stabilized analog |
| Databáze: | OpenAIRE |
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