Effect of abatacept treatment on serum osteoclast-related biomarkers in patients with rheumatoid arthritis (RA)
| Autor: | Kawashiri, Shin-Ya, Endo, Yushiro, Nishino, Ayako, Okamoto, Momoko, Tsuji, Sosuke, Takatani, Ayuko, Shimizu, Toshimasa, Sumiyoshi, Remi, Koga, Tomohiro, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Aramaki, Toshiyuki, Ueki, Yukitaka, Yoshitama, Tamami, Eiraku, Nobutaka, Matsuoka, Naoki, Okada, Akitomo, Fujikawa, Keita, Hamada, Hiroaki, Nagano, Shuji, Tada, Yoshifumi, Kawakami, Atsushi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
musculoskeletal diseases
rheumatoid arthritis TRACP-5b Male abatacept Observational Study Osteoclasts Severity of Illness Index Arthritis Rheumatoid Japan Humans Prospective Studies Aged sRANKL Aged 80 and over Tartrate-Resistant Acid Phosphatase RANK Ligand Remission Induction C-Reactive Protein Methotrexate Antirheumatic Agents Female musculoskeletal ultrasound Biomarkers Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | We evaluated the effect of abatacept treatment on osteoclast-related biomarkers and explored whether the biomarkers are associated with the therapeutic response in rheumatoid arthritis (RA) patients treated with abatacept. We enrolled 44 RA patients treated with abatacept from a multicenter prospective ultrasound cohort study of patients who received biologic or targeted synthetic disease-modifying antirheumatic drug therapy. We evaluated the disease activity score (DAS) 28-CRP (C-reactive protein), musculoskeletal ultrasound scores including the total grayscale score (GS)/power Doppler (PD) score and the serum concentrations of isoform 5b of tartrate-resistant acid phosphate (TRACP-5b) and soluble receptor activator of nuclear factor-κB ligand (sRANKL) at baseline and at 3 and 6 months of treatment. “PD responder” was defined as a patient whose Δtotal PD score over 6 months was greater than the median change of that. Abatacept significantly improved DAS28-CRP as well as the total GS/PD score over 6 months. Serum TRACP-5b was significantly elevated and serum sRANKL was significantly decreased at 6 months (P |
| Databáze: | OpenAIRE |
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