Autor: |
Sana, Zahid, Mehreen, Gul, Shagufta, Shafique, Sajid, Rashid |
Rok vydání: |
2022 |
Předmět: |
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Zdroj: |
Computers in biology and medicine. 146 |
ISSN: |
1879-0534 |
Popis: |
Homologous to E6AP carboxyl-terminus (HECT)-type E3 ligase performs ubiquitin (Ub)-proteasomal protein degradation via forming a complex with E2∼Ub. Enveloped viruses including SARS-CoV-2 escape from the infected cells by harnessing the E-class vacuolar protein-sorting (ESCRT) machinery and mimic the cellular system through PPAY motif-based linking to HECT Ub ligase activity. In the present study, we have characterized the binding pattern of E2 |
Databáze: |
OpenAIRE |
Externí odkaz: |
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