| Autor: |
E, Nyilas, T H, Chiu, R L, Sidman, E W, Henry, T M, Brushart, P, Dikkes, R, Madison |
| Rok vydání: |
1983 |
| Předmět: |
|
| Zdroj: |
Transactions - American Society for Artificial Internal Organs. 29 |
| ISSN: |
0066-0078 |
| Popis: |
Using the transected sciatic nerve model in adult mice, regeneration of a large bundle of axons organized into the form of a nerve with myelinated and unmyelinated axons, Schwann cells, fibroblasts, collagen, blood vessels, and connective tissue sheaths has been achieved with bioresorbable microtubular guidance channels over gaps of 5 mm in nonimmobilized animals. After 4-6 wks postoperatively, the regenerated nerve cable contains on the order of 40% as many myelinated axons as were measured in the proximal nerve stumps. With the channels used so far in this model, regenerating axons pass into the distal stump in about 3-6 wks postoperatively. The guidance channels used consist of synthetic polyesters and/or polyester composites including glycolic and lactic acid polymers, and polyesters derived from Krebs Cycle dicarboxylic acids. Inflammatory response to these materials has been minimal. Biodegradation/resorption rates can be controlled so as to be compatible with axon growth rates. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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