| Autor: |
Guo-hua, Fan, Jian-ping, Gong, Jun-kang, Shen, Cai-yuan, Zhang, Xiao-qiu, Xu, Liang, Xu, Ze-yang, Yu, Wei, Zhang, Hao-rong, Wu |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Zhonghua yi xue za zhi. 93(5) |
| ISSN: |
0376-2491 |
| Popis: |
To explore the values of magnetic resonance spectrum (MRS) in early diagnosis, quantization analysis and staging of hepatic fibrosis.A rat model of hepatic fibrosis was established by the method of carbon tetra carbon (CCl4). A total of 47 SD rats were divided into model (n = 40) and control (n = 7) groups. 1H-MRS was performed. The model rats of hepatic fibrosis were grouped according to their pathological stages. The ratio of peak height and peak area of metabolites and lipid (Cho/Lip, Glx/Lip, Lac/Lip and Cr/Lip) were calculated and compared respectively.The ratios of peak height of metabolites and lipid were as follows: ratio of Cho and Lip: significant differences existed between control and grades 3 and 4 model groups (P0.05); ratio of Glx and Lip: significant differences existed between control and grades 2, 3 and 4 model groups (P0.05); ratio of Cr and Lip: significant differences existed between control and grade 3 model groups (P0.05). The peak area ratio of main metabolites and lipid of liver were as follows: ratio of Cho and Lip: significant differences existed between control and grade 4 model groups (P0.05); ratio of Glx and Lip: significant differences existed between control and other groups (P0.05); ratio of Cr and Lip: significant differences existed between control and grade 4 model groups (P0.05); ratio of Lac and Lip: no significant differences existed between these groups (P0.05).The ratios of peak height and peak area of Cho/Lip, Glx/Lip and Cr/Lip are important for the staging of hepatic fibrosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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