Sinus floor augmentation with simultaneous placement of dental implants using a combination of deproteinized bone xenografts and recombinant human osteogenic protein-1. A histometric study in miniature pigs
| Autor: | H, Terheyden, S, Jepsen, B, Möller, M M, Tucker, D C, Rueger |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Minerals
Bone Regeneration Bone Transplantation Swine Bone Morphogenetic Protein 7 Dental Implantation Endosseous Maxillary Sinus Recombinant Proteins Osteogenesis Transforming Growth Factor beta Bone Morphogenetic Proteins Bone Substitutes Animals Humans Swine Miniature Cattle Female Oral Surgical Procedures Preprosthetic |
| Zdroj: | Clinical oral implants research. 10(6) |
| ISSN: | 0905-7161 |
| Popis: | Maxillary sinus floor augmentation with autogenous bone has become a widely accepted procedure in implant dentistry. The use of osteoconductive bone substitutes in this indication is controversial, since their use can lead to a prolonged healing time, inhomogenous ossification, foreign body reaction, migration of particles and low bone-implant contact (BIC). The purpose of this study was to examine whether the combination of an osteoinductive protein (recombinant human osteogenic protein-1 (rhOP-1 = bone morphogenetic protein-7) with natural bovine bone mineral (BioOss) would improve ossification and the bone-implant contact (BIC) in a sinus floor augmentation with simultaneous placement of implants. In this study, the maxillary sinus floors in 5 miniature pigs were augmented with 3 ml BioOss containing 420 micrograms rhOP-1 on the test side and 3 ml BioOss alone on the control side. At the time of augmentation a titanium implant (ITI) was inserted from a laterocaudal direction. After 6 months of healing the sites of augmentation were removed and examined in non-decalcified sections by microradiography, fluorescence microscopy of sequentially labelled specimens and by histometry. On both sides, significant amounts of newly-formed bone were observed. However, on the test sites, the percentage of BIC in the augmented area was 80.0% versus 38.6% on control sites. It can be concluded that the application of bone morphogenetic proteins caused a more rapid and enhanced osseointegration of simultaneously placed implants when compared to the bone substitute alone. Therefore recombinant human osteogenic protein-1 delivered by natural bone mineral has the potential to become a clinical alternative for autogenous bone grafts in sinus floor augmentation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text