[Analysis of the mechanism of the stress-protective action of delta sleep-inducing peptide]

Autor: R Iu, Iukhananov, V V, Rozhanets, I I, Mikhaleva, A I, Maĭskiĭ
Rok vydání: 1990
Předmět:
Zdroj: Biulleten' eksperimental'noi biologii i meditsiny. 109(1)
ISSN: 0365-9615
Popis: By RIA there were studied the contents of corticosterone, ACTH, beta-endorphin and insulin in the blood plasma, met- and leu-enkephalin in different regions of the rat brain and in the adrenal glands after a 6-hour immobilization. The stress increased the content of corticosterone, ACTH, beta-endorphin, but not insulin in the blood plasma, and the levels of met-enkephalin in the adrenal glands, but decreased the met-enkephalin contents in the striatum. The injection of DSIP (0.1 mg/kg, i/p) blocked partly the elevation of corticosterone only. The authors propose, that stress-protective action of DSIP is realized with the involvements of the hypothalamo-pituitary-adrenal gland system.
Databáze: OpenAIRE