Genetically modified clostridium for gene therapy of tumors

Autor: M E, Fox, M J, Lemmon, A J, Giaccia, N P, Minton, J M, Brown
Rok vydání: 2011
Zdroj: Methods in molecular medicine. 35
ISSN: 1543-1894
Popis: Many murine and human tumors contain hypoxic or necrotic regions in which the oxygen tension is abnormally low. For example,50% of primary tumors of the breast, cervix, and head and neck contain areas that are hypoxic. Because hypoxic regions are not present in normal tissue, this provides the potential for selectively targeting gene therapy to tumor cells.
Databáze: OpenAIRE