| Autor: |
John, Koskinas, Melanie, Deutsch, Dimitris, Kountouras, Georgia, Kostopanagiotou, Nikos, Arkadopoulos, Vasilis, Smyrniotis, Irene, Rapti, Emmanuel, Manesis, Athanasios, Archimandritis |
| Rok vydání: |
2008 |
| Zdroj: |
Liver international : official journal of the International Association for the Study of the Liver. 28(6) |
| ISSN: |
1478-3231 |
| Popis: |
Introduction: In Western countries, the most frequent aetiology of acute liver failure (ALF) is acetaminophen overdose, while in developing countries viral infections [hepatitis A virus and hepatitis B virus (HBV)] predominate. Aim: To evaluate the epidemiology, clinical characteristics, outcome and prognostic factors of survival of patients with ALF in Greece during the last 6 years. Results: A total of 40 patients, 28 females (70%), with a median age of 37.4+/-18.6 years (range: 15-84) with ALF were studied. HBV infection was the cause in 53% of them (compared with 74% from a previous study reported in the early 1980s), drug toxicity in 15% and undetermined in 13%. The overall survival was 57.5%, including 94% with and 15% without liver transplantation. Forty-five per cent of our patients had emergency liver transplantation in European Centers within a median time of 3.3 days (1-9) from admission. The total bilirubin level at admission and the development of infections were found to be significantly associated with poor outcome. Conclusions: Hepatitis B virus still remains the most important cause of ALF in Greece, but shows a significant decrease as compared with studies in the early 1980s. Almost half of our patients needed emergency liver transplantation and had a very good survival rate. The other 15% of the patients presented spontaneous survival only with intensive medical support. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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