| Autor: |
Alistair, Mathie, Emma L, Veale, Alessia, Golluscio, Robyn G, Holden, Yvonne, Walsh |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Handbook of experimental pharmacology. 267 |
| ISSN: |
0171-2004 |
| Popis: |
In this review, we consider the pharmacology of potassium channels from the perspective of these channels as therapeutic targets. Firstly, we describe the three main families of potassium channels in humans and disease states where they are implicated. Secondly, we describe the existing therapeutic agents which act on potassium channels and outline why these channels represent an under-exploited therapeutic target with potential for future drug development. Thirdly, we consider the evidence desired in order to embark on a drug discovery programme targeting a particular potassium channel. We have chosen two "case studies": activators of the two-pore domain potassium (K |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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