| Autor: |
M E, Herrera-Gutiérrez, G, Seller-Pérez, G, Quesada García, M M, Granados, J M, Domínguez, R J, Gómez-Villamandos |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Medicina intensiva. 35(2) |
| ISSN: |
1578-6749 |
| Popis: |
To define a septic shock experimental model that can be used in for training in the early management of septic shock, specifically by extracorporeal depuration (ECD).A case-control experimental study.Veterinary university hospital.Ten Beagle dogs (weight 12-15kg).Shock was induced using 1mg/kg Escherichia coli lipopolysaccharide (LPS) diluted in 20 mL saline infused in 10 minutes, with a subsequent follow-up at 6 hours. There was no intervention in 5 animals in order to define the natural course of the shock and 5 underwent high volume hemofiltration (HVHF, 100mL/kg/h) to define delay in response to treatment.Pressures (arterial and pulmonary), hemodynamic parameters, gastric tonometry and respiratory function were recorded.The LPS effect was evidenced at 2 minutes of the infusion and the 10 animals showed severe shock at the end of the infusion. At 2-hours, changes between treated and non-treated animals were seen in cardiac output, systolic volume variability and mucous CO(2). Mean arterial pressure was significantly different at four hours. All non-treated subjects died during the 6-hour follow-up and all the treated animals survived for this period. Based on these results, we developed a workshop that has been used in five courses (www.ccmijesususon.com - www.crrtcordoba.com.es/), obtaining the previous results.Our shock model shows a predictable behavior, very short latency and a sufficiently rapid improvement in the treated animals for it to be applied in training workshops. It is useful for training in the high-volume hemofiltration (HVHF) and can be used for training in the early management of septic shock. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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