[Elevated Na+/H+ exchange in erythrocytes of patients with hypertension]

Autor: S N, Orlov, I Iu, Postnov, N I, Pokudin, V Iu, Kukharenko, Postnov Iuv
Rok vydání: 1988
Předmět:
Zdroj: Biulleten' eksperimental'noi biologii i meditsiny. 106(9)
ISSN: 0365-9615
Popis: The kinetics of proton efflux from erythrocytes with acidified cytoplasm (pHi 6.4) in a medium with pH 8.0 has been studied. The participation of the anion exchanger in this process was blocked by a stilbene disulfonic acid derivative. It was shown that the rate of Na+/H+ exchange (amiloride-inhibited component of proton efflux) is increased 2 fold. The addition of protein kinase C activator (1 microM of TPA) results in the increase of the rate of Na+/H+ exchange by 4 fold.
Databáze: OpenAIRE