Autor: |
Jing-Qiu, Ma, Xiao-Yang, Sheng |
Rok vydání: |
2011 |
Předmět: |
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Zdroj: |
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. 13(9) |
ISSN: |
1008-8830 |
Popis: |
Faltering linear growth is commonly encountered in children with intestinal inflammation. Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are important regulators of postnatal longitudinal bone growth. Inhibition of GH/IGF axis will result in growth failure in young children. Pro-inflammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) abnormally increase in children with intestinal inflammation, and may affect linear growth both systemically and locally at the level of the growth plate though disturbing the GH/IGF axis. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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