| Autor: |
Adrien, Carabelli, Marjorie, Canu, Marie, de Fondaumière, Marlène, Debiossat, Julien, Leenhardt, Alexis, Broisat, Catherine, Ghezzi, Gérald, Vanzetto, Daniel, Fagret, Gilles, Barone-Rochette, Laurent M, Riou |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
European journal of nuclear medicine and molecular imaging. 49(3) |
| ISSN: |
1619-7089 |
| Popis: |
Coronary microvascular dysfunction (CMVD) plays a major role in the occurrence of cardiovascular events (CVE). We recently suggested the clinical potential of myocardial perfusion entropy (MPE) quantification from SPECT myocardial perfusion images (MPI) for the prognosis of CVE occurrence. We hypothesized that the quantification of MPE from SPECT MPI would allow the assessment of CMVD-related MPE variations in a preclinical model of type 2 diabetes (T2D) including treatment with the anti-diabetic incretin liraglutide (LIR).Optimal conditions for the preclinical quantification of MPE usingThe feasibility study identified dobutamine stress and acute NO synthase and cyclooxygenase inhibition as optimal conditions for the quantification of MPE, with significant increases in MPE being observed in T2D animals (P 0.01 vs controls). In the therapeutic study, T2D rats were hyperglycemic (5.5 ± 0.5 vs 1.1 ± 0.3 g/L for controls, P 0.001) and had a significantly lower left ventricular ejection fraction (LVEF) (65 ± 4% vs 74 ± 9%, P 0.01) and LV capillary density (2400 ± 300 vs 2800 ± 600 mmMPE quantification allowed the preclinical noninvasive assessment of CMVD. Both MPE and capillary density quantification suggested that LIR did not improve T2D-induced CMVD. The relevance of MPE for CMVD assessment warrants further clinical investigation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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