[Apelin attenuates hypoxia induced pulmonary hypertension of mice through regulation of lipid metabolism]

Autor:	Ran, Chen, Pu, Jiang, Ling-Yan, Liu, Yuan, Gao, Xin-Xin, Yang, Zhuo-Chang, Cai, Xiao-Fang, Fan, Yong-Sheng, Gong, Sun-Zhong, Mao
Rok vydání:	2018
Předmět:	Male Mice Knockout ApoE Hypertension Pulmonary Scavenger Receptors Class B Lipid Metabolism PPAR gamma Mice Random Allocation Cholesterol Animals Apelin Hydroxymethylglutaryl CoA Reductases Hypoxia Lung ATP Binding Cassette Transporter 1
Zdroj:	Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 33(6)
ISSN:	1000-6834
Popis:	To observe the role of apelin in the prevention of pulmonary hypertension induced by hypoxia in mice.Adult male apoE gene knockout (apoE-KO) mice were exposed to isobaric hypoxic chamber (9%~11% O①The right ventricular systolic pressure (RVSP) and the weight ratio of right ventricle (RV) to left ventricle plus septum (LV+S) of hypoxia group were significantly higher than those of normoxia group by 87% and 85% (Apelin attenuates hypoxia-induced pulmonary hypertension of mice through regulation of lipid metabolism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::84e22a50d771e35e16afeea23cde69e9 https://pubmed.ncbi.nlm.nih.gov/29931896 Zobrazit plný text záznamu