| Autor: |
Rodolfo Furlan, Damiano, Julia Cunha, Loureiro, Marcos Vasconcelos, Pais, Rodrigo Furtado, Pereira, Marina de Menezes, Corradi, Talita Di, Santi, Gustavo Antonio Marcolongo, Bezerra, Márcia, Radanovic, Leda Leme, Talib, Orestes Vicente, Forlenza |
| Rok vydání: |
2022 |
| Zdroj: |
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). |
| ISSN: |
1809-452X |
| Popis: |
To re-evaluate a sample of older adults enrolled in a randomized controlled trial (RCT) using lithium for treatment of amnestic mild-cognitive impairment (MCI) after 11 to 15 years, by re-assessing their current (or last available) global cognitive and functional state.We recalled all former participants of the 'Lithium-MCI' trial conducted by our group between 2009 and 2012 to perform a single-blinded, cross-sectional evaluation of their global clinical state, in order to compare the long-term outcome of subjects previously allocated in lithium group vs. those who received placebo.From the original sample (n=61), we were able to reach for 36 participants (59% of retention), of whom 22 had previously received lithium (61% of the recall sample), and 14 (39%) had received placebo. As 30.5% of recalled sample was deceased, psychometric data was collected only for 69.5% of our participants. We found statistically significant differences in current mean mini mental state examination score according to previous treatment groups (25.5 [5.3] vs. 18.3 [10.9], p=0.04). These subjects also had better performance in the phonemic verbal fluency test compared to non-users (34.4 [14.4] vs. 11.6 [10.10], p0.001). Differences in these measures also displayed large effect sizes, as shown by Cohen's d values of 0.92 and 1.78 respectively.The present set of data suggests that older adults with amnestic MCI who had been treated with lithium during a previous RCT had a better long-term global cognitive outcome than those from a matched sample who did not receive the intervention. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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