| Autor: |
A K, Burnett, I M, Hann, A G, Robertson, M, Alcorn, B, Gibson, I, McVicar, L, Niven, S, Mackinnon, H, Hambley, A, Morrison |
| Rok vydání: |
1988 |
| Předmět: |
|
| Zdroj: |
Leukemia. 2(5) |
| ISSN: |
0887-6924 |
| Popis: |
Graft-versus-host disease prevention was attempted in 35 consecutive patients with hematological malignancy who received bone marrow from an HLA match sibling donor who was depleted of T cells ex vivo. Five of the first 8 patients who received cyclophosphamide 60 mg/kg on 2 consecutive days followed by fractionated total body irradiation (TBI) (6 x 2 Gy) had graft failure. The subsequent 27 patients had received an extra fraction of TBI (7 x 2 Gy), and only one failed to have stable engraftment. There were no differences in nucleated cell dose, granulocyte-macrophage colony-forming units, or T cell numbers given to the two groups. Neutrophil but not platelet regeneration of those patients who successfully grafted was slower than in a group of historical controls receiving unmanipulated marrow. Significant graft-versus-host disease was prevented with no increase in relapse rate. We suggest that engraftment can be reliably achieved by augmenting the TBI conditioning in recipients of T cell-depleted matched allogeneic bone marrow. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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