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We have established that danazol is an orally active pituitary gonadotrophin inhibitory agent devoid of oestrogenic and progestational activity. This steroid has weak, impeded androgenic activity. Danazol is unique in possessing such a profound separation of pituitary gonadotrophin inhibitory activity from overt sex hormone activity. Separate studies have shown that danazol is antiandrogenic, anti-progestational and antioestrogenic. Extensive toxicological studies have established the safety of this steroid. Lastly, the metabolic studies provide convincing evidence that danazol is the active steroid. |
