| Autor: |
Sadettin, Demirel, Fadil, Ozyener |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Protein and peptide letters. 29(9) |
| ISSN: |
1875-5305 |
| Popis: |
This study aimed to investigate the effects of irisin on rat tracheal smooth muscle contraction-relaxation responses and the roles of voltage-gated potassium (KIsometric contraction and relaxation responses of tracheal segments were measured using the tissue bath method. Submaximal contractions were induced by ACh (10Irisin exhibited the relaxant effects in tracheal segments precontracted with both ACh and KCl at concentrations of 10In conclusion, the first physiological results on the relaxant effects of irisin in rat trachea were obtained. Our findings demonstrated that irisin mediates concentration-dependent relaxation in rat tracheas. Moreover, the present study reported for the first time that irisin-induced bronchorelaxation is associated with the activity of the K+ channels. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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