| Autor: |
M L, Nieland, A R, Silverman, D, Borochovitz, H L, Saferstein |
| Rok vydání: |
1981 |
| Předmět: |
|
| Zdroj: |
The American Journal of dermatopathology. 3(3) |
| ISSN: |
0193-1091 |
| Popis: |
A case of cutaneous malakoplakia is reported. The patient is a 53-year-old white woman on immunosuppressive therapy 6 years after renal transplantation for end-stage nephrosclerosis. She developed yellow-pink papular lesions in her natal cleft which, on histopathologic examination, showed typical features of malakoplakia, namely, a diffuse dermal infiltrate of histiocytes (von Hansemann cells) which contained calcified Michaelis-Gutmann bodies with a concentric ring appearance. Gram-negative bacteria were also identified in some of the histiocytes. The Michaelis-Gutmann bodies stained positively with the PAS-diastase, mucicarmine, and Grocott stains and thus resembled fungal spores from which they must be differentiated. Electron microscopy showed that the Michaelis-Gutmann bodies developed within phagolysosomes of the histiocytes. Malakoplakia appears to be caused by an acquired defect in the intracellular digestion of phagocytized bacteria. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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