Substituted carboranes and polyhedral hydroborate salts as anti-neoplastics

Autor:	I H, Hall, A, Elkins, W J, Powell, S, Karthikeyan, A, Sood, B F, Spielvogel
Rok vydání:	1998
Předmět:	Boron Compounds Osteosarcoma Leukemia Leukemia T-Cell Lung Neoplasms Molecular Structure Cell Survival Antineoplastic Agents Mice Inbred Strains Glioma Adenocarcinoma KB Cells Mice Drug Design Tumor Cells Cultured Animals Humans Carcinoma Ehrlich Tumor Leukemia L1210 HeLa Cells
Zdroj:	Anticancer research. 18(4A)
ISSN:	0250-7005
Popis:	Substituted carboranes and polyhedral hydroborate salts were observed to be potent anti-neoplastic/cytotoxic agents inhibiting the growth of mouse and human leukemias, human uterine, colon adenocarcinoma, lung bronchogenic and gliomas. Amino-o-carborane-hydrochloride 7, one of the more potent compounds, preferentially inhibited Tmolt3 DNA synthesis. The target of the agent appears to be de novo purine synthesis with significant inhibition of the activities of both regulatory enzymes, PRPP-amido transferase and inosine monophosphate dehydrogenase as well as dihydrofolate reductase. The agent also inhibited nucleoside kinase activities leading to reductions in deoxyribonucleotide pools. The DNA molecule itself was not a target of the agent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::848ce57528d50c74ef1ec8d7767397e4 https://pubmed.ncbi.nlm.nih.gov/9703918 Zobrazit plný text záznamu