Noncanonical activation of GLI signaling in SOX2

Autor: Marzena, Swiderska-Syn, Júlia, Mir-Pedrol, Alexander, Oles, Olga, Schleuger, April D, Salvador, Sean M, Greiner, Cara, Seward, Fan, Yang, Benjamin R, Babcock, Chen, Shen, Daniel T, Wynn, Avencia, Sanchez-Mejias, Timothy R, Gershon, Vanesa, Martin, Heather J, McCrea, Kathryn G, Lindsey, Carsten, Krieg, Jezabel, Rodriguez-Blanco
Rok vydání: 2022
Předmět:
Zdroj: Science advances. 8(29)
ISSN: 2375-2548
Popis: SRY (sex determining region Y)-box 2 (SOX2)-labeled cells play key roles in chemoresistance and tumor relapse; thus, it is critical to elucidate the mechanisms propagating them. Single-cell transcriptomic analyses of the most common malignant pediatric brain tumor, medulloblastoma (MB), revealed the existence of astrocytic
Databáze: OpenAIRE