| Autor: |
Zi, Fu, Wen, Qu, Zong-Hong, Shao, Hua-Quan, Wang, Li-Min, Xing, Xi-Feng, Dong, Zhao-Yun, Liu, Xiao-Na, Li, Yang, Zhang, Shao-Xue, Ding |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Zhongguo shi yan xue ye xue za zhi. 30(4) |
| ISSN: |
1009-2137 |
| Popis: |
To investigate the expression of programmed death receptor-1 (PD-1) and inducible costimulator (ICOS) on the surface of CD8A total of 28 ITP patients treated in Tianjin Medical University General Hospital from September to December 2020 were selected, including 13 patients with newly diagnosed ITP, 15 patients with chronic ITP, and 22 healthy volunteers were recruited as control group. Flow cytometry was used to detect the expression levels of PD-1 and ICOS, and evaluate their correlation with clinical indicators.The percentage of CD8In ITP patients, the unbalanced expression of PD-1 and ICOS may interfere with the immune homeostasis of the body, which can be used as a therapeutic target for ITP patients.PD-1、ICOS在ITP患者中的表达及意义.检测原发免疫性血小板减少症（ITP）患者外周血CD8选取2020年9月至12月于天津医科大学总医院血液科就诊的ITP患者28例，包括 13例新诊断患者，15例慢性患者，同时选取健康志愿者22名作为对照组。采用流式细胞术检测外周血CD8慢性组ITP患者CD8在ITP患者中，PD-1和ICOS的不平衡表达可能干扰机体的免疫稳态，可以作为ITP患者的治疗靶标。. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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