| Autor: |
C J, Theuer, T M, Bergamini, H H, Theuer, C D, Burns, M L, Proctor, R N, Garrison |
| Rok vydání: |
1996 |
| Předmět: |
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| Zdroj: |
ASAIO journal (American Society for Artificial Internal Organs : 1992). 42(4) |
| ISSN: |
1058-2916 |
| Popis: |
The use of the peritoneum as a venous conduit was analyzed because of the inherent fibrinolytic properties of the mesothelium. A canine model in which the infrarenal inferior vena cava was replaced with interposition grafts (2 cm) of either a peritoneal tube, polytetrafluoroethylene (PTFE), or PTFE lined with peritoneum (lined graft) was studied. Venograms were performed 1 and 6 weeks after graft implantation for the percent area reduction of the lumen. Grafts were explanted at 6 weeks for light and scanning electron microscopy. The percent area reduction at 1 week for all grafts was found to be predictive of graft clotting by 6 weeks. At 6 weeks, one of three peritoneal tube grafts (33%), six of seven PTFE grafts (86%), and four of seven lined grafts (57%) were patent. Histologic studies demonstrated that stenosis of PTFE grafts was due to intraluminal thrombus formation, whereas lined grafts stenosed due to granulation tissue growth between the mesothelium and PTFE. A cellular circumferential intraluminal lining was found in four of four lined grafts, but in none of six PTFE grafts (p0.01). Furthermore, none of four lined grafts had intraluminal thrombus, but all of six PTFE grafts did (p0.01). Peritoneum-lined PTFE grafts maintain a continuous circumferential cellular lining, but have no improvement in short-term patency compared to PTFE alone. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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