Synthesis of acetylenic spirobutenolide derivatives and evaluation of their growth inhibitory effect on cells in culture

Autor:	P, Bador, J, Chantepie, J, Paris, G, Quash
Rok vydání:	1990
Předmět:	Magnetic Resonance Spectroscopy Chemical Phenomena Chemistry Physical Antineoplastic Agents Ornithine Decarboxylase Neoplasm Proteins Mannich Bases Chemistry Cell Transformation Neoplastic Humans Spiro Compounds Cell Division Cells Cultured HeLa Cells
Zdroj:	Arzneimittel-Forschung. 40(10)
ISSN:	0004-4172
Popis:	Acetylenic spirobutenolide amides and esters and their Mannich bases were synthesized to evaluate their growth inhibitory effect. The biological tests have used both normal and transformed cells and they have shown the selectivity of the prepared compounds. The ester derivatives presented the best selectivity comparable to that of daunorubicin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8443252690ac9c517114114def8ad4ae https://pubmed.ncbi.nlm.nih.gov/2291752 Zobrazit plný text záznamu