| Autor: |
C, Fenselau, J P, Lehman, A, Myles, J, Brandt, G S, Yost, O M, Friedman, O M, Colvin |
| Rok vydání: |
1982 |
| Předmět: |
|
| Zdroj: |
Drug metabolism and disposition: the biological fate of chemicals. 10(6) |
| ISSN: |
0090-9556 |
| Popis: |
Iminocyclophosphamide has been identified among the metabolites produced by incubation of cyclophosphamide with cytochrome P-450 mono-oxygenase immobilized on beaded Sepharose. The reactive imine was trapped by addition of hydrogen cyanide, and the product, 4-cyanocyclophosphamide, was identified by comparison of its chromatographic and mass-spectral properties with those of a synthetic standard. Iminocyclophosphamide was also generated chemically from 4-hydroperoxycyclophosphamide and characterized both by addition of hydrogen cyanide and by reduction with sodium borodeuteride. The synthesis of authentic 4-cyanocyclophosphamide is also reported. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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