Restriction of T-cell receptor repertoires in idiopathic CD4+ lymphocytopenia

Autor:	S, Signorini, S, Pirovano, S, Fiorentini, R, Stellini, V, Bianchi, A, Albertini, L, Imberti
Rok vydání:	2000
Předmět:	Male Case-Control Studies T-Lymphocytes CD4-CD8 Ratio Receptors Antigen T-Cell Receptors Lymphocyte Homing Humans Female Heteroduplex Analysis Middle Aged Opportunistic Infections T-Lymphocytopenia Idiopathic CD4-Positive Aged
Zdroj:	British journal of haematology. 110(2)
ISSN:	0007-1048
Popis:	We report that alpha/beta and gamma/delta T-cell repertoires of three patients with idiopathic CD4+ lymphocytopenia, who showed different clinical manifestations and outcomes over time, were highly restricted. The disruption of T-cell repertoires does not influence the susceptibility to infections: the first patient was unable to attain a protective response to mycobacterium, the second showed clinical improvement and the third did not develop opportunistic infections. These results indicate that idiopathic CD4+ lymphocytopenia could give rise to mono-/oligoclonal T-cell expansions, but the degree of repertoire disturbance is not indicative of the severity of disease progression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8417df4261a665f57e3f60cdbc7b1647 https://pubmed.ncbi.nlm.nih.gov/10971404 Zobrazit plný text záznamu Plný text