Head, neck, and spines: a role for LIMK-1 in the hippocampus

Autor:	Patrick D, Sarmiere, James R, Bamburg
Rok vydání:	2002
Předmět:	DNA-Binding Proteins Actin Cytoskeleton Mice Learning Disabilities Long-Term Potentiation Synapses Animals Lim Kinases Dendrites Protein Serine-Threonine Kinases Hippocampus Protein Kinases Synaptic Transmission
Zdroj:	Neuron. 35(1)
ISSN:	0896-6273
Popis:	LIM kinase 1 regulates actin filament dynamics through inhibition of ADF/cofilins. Surprisingly, nervous system development in LIM kinase 1 knockout mice is grossly normal, but the animals have deficits in spatial learning, alterations in LTP, and abnormalities in hippocampal dendritic spine structure. The findings are consistent with a role for LIMK-1 in synapse formation and function.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::84065988eeea6292f1abeedc0440e5a5 https://pubmed.ncbi.nlm.nih.gov/12123613 Zobrazit plný text záznamu