| Autor: |
J E, Streim, D W, Oslin, I R, Katz, B D, Smith, S, DiFilippo, T B, Cooper, T, Ten Have |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 8(2) |
| ISSN: |
1064-7481 |
| Popis: |
The authors conducted a randomized, double-blind, 10-week clinical trial of two doses of nortriptyline in eight nursing homes. Sixty-nine patients, average age 79.5 years, were randomized to receive regular doses (60 mg-80 mg/day) vs. low doses (10 mg-13 mg/day) of nortriptyline. Among the more cognitively intact patients, there was a significant quadratic relationship defining a "therapeutic window" for nortriptyline plasma levels and clinical improvement. There were also significant differences in plasma level-response relationships between depressed patients who were cognitively impaired and those who were more cognitively intact. Depression remains a syndrome that responds to specific treatment, even in frail nursing home patients, and those depressions that occur in patients with significant dementia may represent a treatment-relevant condition with a different plasma level-response relationship than in depression alone. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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