| Autor: |
D, Green, G, O'Driscoll, J M, Rankin, A J, Maiorana, R R, Taylor |
| Rok vydání: |
1998 |
| Předmět: |
|
| Zdroj: |
Clinical science (London, England : 1979). 95(3) |
| ISSN: |
0143-5221 |
| Popis: |
1. Vitamin E administration improves endothelial function in hypercholesterolaemic animals but, generally, has not been found to do so in man. The aim of this study was to determine whether vitamin E administration improves basal or stimulated function of the nitric oxide (NO) dilator system in patients with hypercholesterolaemia. 2. Seven subjects aged 47+/-3 (+/-S.E.M.) years with moderately elevated serum cholesterol concentrations (6.0+/-0.1 mmol/l) were given 4 weeks of placebo therapy followed by 500 i.u. of vitamin E twice daily for 4 weeks. Endothelium-dependent and -independent vasodilatation were assessed by intrabrachial infusion of acetylcholine and sodium nitroprusside, and forearm blood flow was measured by strain-gauge plethysmography. Basal NO function was assessed by infusion of NG-monomethyl-L-arginine. 3. Plasma alpha-tocopherol concentration was enhanced after administration of vitamin E (34.6+/-1.8 to 86.9+/-9.6 micromol/l; P0.001). In addition, vitamin E administration significantly increased acetylcholine-mediated vasodilatation whether the results were expressed in terms of changes in absolute forearm blood flow (P0. 01), forearm vascular resistance (P0.05) or forearm blood flow ratios (P0.001). Similarly, absolute forearm blood flow (P0.05), forearm vascular resistance (P0.01) and forearm blood flow ratio (P0.01) responses to NG-monomethyl-L-arginine were augmented by vitamin E therapy. Sodium nitroprusside responses were unaltered. 4. These results indicate that 4 weeks therapy with 1000 i.u. of vitamin E daily improves basal and stimulated NO-related endothelial function in subjects with hypercholesterolaemia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
