| Autor: |
Y, Matsumoto, M, Oka, A, Sakamoto, F, Narasaki, M, Fukuda, H, Takatani, K, Terashi, K, Ikeda, J, Tsurutani, S, Nagashima, H, Soda, S, Kohno |
| Rok vydání: |
1998 |
| Předmět: |
|
| Zdroj: |
Anticancer research. 17(5B) |
| ISSN: |
0250-7005 |
| Popis: |
Metallothioneins (MTs) are induced by various stimuli and probably confer drug resistance in tumor cells in vitro. To investigate whether MT expression in lung cancer is induced by chemotherapy, ninety-seven surgical specimens from patients who had or not received chemotherapy containing cisplatin, were stained immunohistochemically for MT. In untreated tumors, 23% (15/64) of all tumors and 27% (15/56) of non-small-cell carcinoma (NSCLC) stained positive, while all eight small-cell carcinoma (SCLC) were negative. In treated tumors, 52% (17/33) of all tumors, 80% (12/15) of NSCLC and 28% (5/18) of SCLC stained positive. The proportion of positively-stained tumors was significantly higher in treated NSCLC compared with untreated NSCLC (P = 0.0005) and treated SCLC (P0.005). Our results indicate that MT expression increases following chemotherapy and that such expression may confer during resistance in lung cancer, especially NSCLC. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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