Modification of motoneuron size after partial denervation in neonatal rats
| Autor: | F, Tyc, G, Vrbová |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Motor Neurons
Time Factors Action Potentials Cell Polarity Axotomy Denervation Axons Rats Disease Models Animal Muscle Fibers Slow-Twitch Phenotype Animals Newborn Peripheral Nerve Injuries Muscle Fibers Fast-Twitch Animals Peripheral Nerves Rats Wistar Coloring Agents Muscle Skeletal Cell Shape Horseradish Peroxidase Cell Size Muscle Contraction |
| Zdroj: | Archives italiennes de biologie. 145(3-4) |
| ISSN: | 0003-9829 |
| Popis: | Our previous studies have shown that partial denervation of extensor digitorum longus muscle (EDL) in the rat at 3 days of age causes an increase in the activity of the intact motoneurons. The originally phasic pattern of activity of EDL became tonic after partial denervation. These modifications of motoneuron activity were associated with the change in the phenotype of the muscle from fast to slow contracting and with a conversion of the muscle fibres from a fast to a slow type. The present study investigates whether the size of the cell body of the active EDL motoneurons change in parallel with the altered muscular activity. The study involved partial denervation of rat EDL muscle by section of the L4 spinal nerve at 3 days of age. Then the remaining motoneurons from L5 spinal nerve supplying the EDL muscle were retrogradly labelled with horseradish peroxidase two months later. The results show a reduction in motoneuron size in parallel with an increase in activity of the motoneurons after partial denervation of EDL muscle. |
| Databáze: | OpenAIRE |
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