[Bilateral optic neuropathy revealing systemic sarcoidosis]

Autor:	P, Guilpain, M A, Andreu, N, Cassoux, D, Le Thi Huong-Boutin, F, Jaeger-Bizet, X, Nasica, C, Chapelon-Abric, B, Wechsler, P, Lehoang, J C, Piette
Jazyk:	francouzština
Rok vydání:	2004
Předmět:	Adult Male Time Factors Sarcoidosis Anti-Inflammatory Agents Antibodies Monoclonal Blindness Infliximab Optic Atrophy Diabetes Mellitus Type 1 Methotrexate Optic Nerve Diseases Humans Prednisone Drug Therapy Combination Immunosuppressive Agents Follow-Up Studies
Zdroj:	La Revue de medecine interne. 25(10)
ISSN:	0248-8663
Popis:	Although ocular involvement concerns about 25 to 60% of patients with systemic sarcoidosis, papilledema is a rare event.A 43-year-old man presented with left visual loss related to papillitis. Despite high-dose corticosteroids, visual loss became rapidly bilateral. Thoracic CT-scan showed mediastinal and parenchymal involvement. Histological study of lung, bronchial and lymphadenopathy biopsies displayed giant-cells granuloma without necrosis. Diagnosis of sarcoidosis complicated with optic neuropathy was made. Therapy combining prednisone, methotrexate and infliximab was started without significant improvement of visual acuity.This report underlines the potential severity of optic neuropathy in sarcoidosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::83c7bf87b21727cbbe8ceb036e5a659f https://pubmed.ncbi.nlm.nih.gov/15471602 Zobrazit plný text záznamu Full Text from ScienceDirect