Elastase- and LPS-Exposed Cpa3
| Autor: | Eduardo I, Cardenas, Perla A, Alvarado-Vazquez, Erika, Mendez-Enriquez, Erik A, Danielsson, Jenny, Hallgren |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Frontiers in immunology. 13 |
| ISSN: | 1664-3224 |
| Popis: | IL-33 and its receptor ST2, as well as mast cells and their mediators, have been implicated in the development of chronic obstructive pulmonary disease (COPD). However, whether mast cells and the ST2 receptor play a critical role in COPD pathophysiology remains unclear. Here, we performed repeated intranasal administrations of porcine pancreatic elastase and LPS for four weeks to study COPD-like disease in wildtype, ST2-deficient, and Cpa3 |
| Databáze: | OpenAIRE |
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