| Autor: |
W R, Hiatt, J G, Regensteiner, M A, Creager, A T, Hirsch, J P, Cooke, J W, Olin, G N, Gorbunov, J, Isner, Y V, Lukjanov, M S, Tsitsiashvili, T F, Zabelskaya, A, Amato |
| Rok vydání: |
2001 |
| Předmět: |
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| Zdroj: |
The American journal of medicine. 110(8) |
| ISSN: |
0002-9343 |
| Popis: |
We tested the hypothesis that propionyl-L-carnitine would improve peak walking time in patients with claudication. Secondary aims of the study were to evaluate the effects of propionyl-L-carnitine on claudication onset time, functional status, and safety.In this double-blind, randomized, placebo-controlled trial, 155 patients with disabling claudication from the United States (n = 72) or Russia (n = 83) received either placebo or propionyl-L-carnitine (2g/day orally) for 6 months. Subjects were evaluated at baseline and 3 and 6 months after randomization with a graded treadmill protocol at a constant speed of 2 miles per hour, beginning at 0% grade, with increments in the grade of 2% every 2 minutes until maximal symptoms of claudication forced cessation of exercise. Questionnaires were used to determine changes in functional status.At baseline, peak walking time was 331 +/- 171 seconds in the placebo group and 331 +/- 187 seconds in the propionyl-L-carnitine group. After 6 months of treatment, subjects randomly assigned to propionyl-L-carnitine increased their peak walking time by 162 +/- 222 seconds (a 54% increase) as compared with an improvement of 75 +/- 191 seconds (a 25% increase) for those on placebo (P0.001). Similar improvements were observed for claudication onset time. Propionyl-L-carnitine treatment significantly improved walking distance and walking speed (by the Walking Impairment Questionnaire), and enhanced physical role functioning, reduced bodily pain, and resulted in a better health transition score (by the Medical Outcome Study SF-36 Questionnaire). The incidence of adverse events and study discontinuations were similar in the two treatment groups.Propionyl-L-carnitine safely improved treadmill exercise performance and enhanced functional status in patients with claudication. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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