| Autor: |
Nasser, Sakran, Ron, Dar, Ahmad, Assalia, Ziv, Neeman, Moaad, Farraj, Shiri, Sherf-Dagan, Ian M, Gralnek, Rawi, Hazzan, Shams Eldin, Mokary, Hadar, Nevo-Aboody, Tamar, Dola, Uri, Kaplan, Dan, Hershko |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Updates in surgery. 72(4) |
| ISSN: |
2038-3312 |
| Popis: |
Although bariatric surgery (BS) predisposes patients to development of gallstone formation, a preventive strategy is still in debate.To compare the incidence of gallstone formation between patients treated with ursodeoxycholic acid (UDCA) vs. placebo for a duration of 6 months following BS.This multicenter randomized, double-blind controlled trial entails treatment with UDCA vs. an identical-looking placebo. The primary outcome was gallstone formation, as measured by abdominal ultrasound.The data of 209 subjects were enrolled in the study, and 92 subjects completed the study and were analyzed (n = 46 for each study group). The high dropout rate was mainly due to difficulties in adding more medications and swallowing the pill. Among the subjects who completed the study, 77.2% were women, and their mean age and pre-surgery BMI were 42.2 ± 10.2 years and 44.4 ± 6.1 kg/mAdministration of UDCA significantly decreased gallstone formation at 6 months at following BS. CLINICALTRIALS.NCT02319629. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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