| Autor: |
A Y, Jeantet, C, Ballan-Dufrançais, C, Petter, M, Truchet |
| Jazyk: |
francouzština |
| Rok vydání: |
1992 |
| Předmět: |
|
| Zdroj: |
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. 315(10) |
| ISSN: |
0764-4469 |
| Popis: |
A single injection of a massive dose of Al-gluconate (4 mg.kg-1) into the saphenous vein of the rat did not provoke any ultrastructural damage in the liver cells, from 2 min. to 8 days after the injection. Al hepatocytes overload appeared only in nuclei and not in nuclei and not in lysosomes, contrarily to chronic intoxications. Nuclear Al concentration concerned only a small fraction of the quantity injected; another part was sequestered by the macrophage system after precipitation in the blood as phosphates chemically transformed during their incorporation in lysosomes. This effective detoxication mechanism which functioned probably after a first absorption by the hepatocyte, was likely to depend upon the form of gluconate and would explain the resistance of liver cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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