| Autor: |
Deepali, Gupta, Thangaraj, Devadoss, Shvetank, Bhatt, Baldev, Gautam, Ankur, Jindal, Dilip, Pandey, Radhakrishnan, Mahesh |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Indian journal of experimental biology. 49(8) |
| ISSN: |
0019-5189 |
| Popis: |
N-Cyclohexyl-3-methoxyquinoxalin-2-carboxamide (QCM-13), a novel 5-HT3 antagonist identified from a series of compounds with higher pA2 (7.6) and good log P (2.91) value was screened in rodent models of depression such as forced swim test (FST), tail suspension test (TST), interaction studies with standard anti-depressants and confirmatory studies such as reversal of parthenolide induced depression and reserpine induced hypothermia. In FST (2 and 4 mg/kg) and TST (2 and 4 mg/kg), QCM-13 significantly reduced the duration of immobility in mice without affecting the base line locomotion. QCM-13 (2 and 4 mg/kg) was also found to have significant interaction with standard anti-depressants (fluoxetine and bupropion in FST and TST respectively). Further, reversal of parthenolide induced depression in mice and reserpine induced hypothermia in rat models indicate the serotonergic influence of QCM-13 for anti-depressant potential. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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