Differential induction of adhesion molecule and chemokine expression by LTalpha3 and LTalphabeta in inflammation elucidates potential mechanisms of mesenteric and peripheral lymph node development
| Autor: | C A, Cuff, R, Sacca, N H, Ruddle |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Inflammation
Membrane Proteins Mice Transgenic Receptors Tumor Necrosis Factor Rats Chemokine CXCL10 Disease Models Animal Islets of Langerhans Mice Antigens CD Receptors Tumor Necrosis Factor Type I Antigens Surface Chronic Disease Animals Mesentery Lymph Nodes Chemokines Inflammation Mediators Cell Adhesion Molecules Chemokine CCL5 Chemokines CXC Lymphotoxin-alpha Chemokine CCL2 |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 162(10) |
| ISSN: | 0022-1767 |
| Popis: | Lymphotoxin (LT) is a member of the proinflammatory TNF family of cytokines that plays a critical role in the development of lymphoid tissue. It has previously been reported that the presence of the LTalpha transgene under the control of the rat insulin promoter results in inflammation at the sites of transgene expression. LTalpha transgene expression results in expression of the adhesion molecules VCAM, ICAM, peripheral node addressin (a marker of peripheral lymph nodes), and mucosal addressin cellular adhesion molecule (a marker of mucosal lymphoid tissue, including mesenteric lymph nodes). In this study to determine the mechanisms by which LT promotes inflammation and lymphoid tissue organization, we analyzed the regulation of expression of adhesion molecules and chemokines in LT transgenic mice. The results demonstrate that LTalpha3 induces expression of the adhesion molecules VCAM, ICAM, and mucosal addressin cellular adhesion molecule as well as the chemokines RANTES, IFN-inducible protein-10, and monocyte chemotactic protein-1, while LTalphabeta is required for the induction of peripheral node addressin that may contribute to the recruitment of L-selectinhigh CD44low naive T cells. These data provide candidate mediators of LT-induced inflammation as well as potential mechanisms by which LTalpha and LTalphabeta may differentially promote the development of mesenteric and peripheral lymph nodes. |
| Databáze: | OpenAIRE |
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