Regulation of the renin–angiotensin system in coronary atherosclerosis: A review of the literature

Autor:	Hammoud, Ramadan A, Vaccari, Christopher S, Nagamia, Sameer H, Khan, Bobby V
Jazyk:	angličtina
Rok vydání:	2007
Předmět:	Clinical Trials as Topic vasculature endothelium Angiotensin-Converting Enzyme Inhibitors Review Coronary Artery Disease angiotensin II Lipid Metabolism Renin-Angiotensin System Glucose inflammation Renin Humans atherosclerosis Angiotensin II Type 1 Receptor Blockers
Zdroj:	Vascular Health and Risk Management
ISSN:	1178-2048 1176-6344
Popis:	Activation of the renin-angiotensin system (RAS) is significant in the pathogenesis of cardiovascular disease and specifically coronary atherosclerosis. There is strong evidence that the RAS has effects on the mechanisms of action of atherosclerosis, including fibrinolytic balance, endothelial function, and plaque stability. Pharmacological inhibition of the renin angiotensin system includes angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and renin inhibitors. These agents have clinical benefits in reducing morbidity and mortality in the management of hypertension. In addition, ACE inhibitors and ARBs have shown to be effective in the management of congestive heart failure and acute myocardial infarction. This review article discusses the biochemical and molecular mechanisms involving the RAS in coronary atherosclerosis as well as the effects of RAS inhibition in clinical studies involving coronary atherosclerosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::82f068aa43f9234a8cbac4c4542ca6ae http://europepmc.org/articles/PMC2350139 Zobrazit plný text záznamu